Research Simplified with Dominique Lessard

Dominique Lessard collaborated with KIF1A.ORG to explain the KIF1A research being led by her and others at Berger Lab. Through this research we learn what distinguishes the KIF1A motor protein as one of the most effective at cargo transport.

In this edition of Research Simplified, we’ll take Dominique’s research paper, “Regulation of KIF1A motility via polyglutamylation of tubulin C-terminal tails,” and simplify it for the KIF1A community.

Follow-Up Interview


  1. 1
    Millie R on August 29, 2019

    Thank you for sharing your time Shannon and Dominque. Julianna has been on the mito-cocktail. has anyone investigated this any further? Use of it? Contacting UMDF about their patient pool of “unspecified” miot like Julianna.
    Thank you,

    1. 2
      katatchley on September 1, 2019

      I would contact Chung Lab to see if they have any information.

  2. 3
    millie ro on August 29, 2019

    Sorry I am back. I know Julianna has a De novo finding. Yet I see my siblings and cousins with boys have mild forms of Aspergers. Any correlation’s?
    Thank you again for your time.
    Millie R.

    1. 4
      katatchley on September 1, 2019

      I would also contact Chung Lab to get their expert input.

  3. 5

    […] got a paper for you. MTs are especially important for motor proteins (like KIF1A). In a past Research Simplified summary, KIF1A researcher Dominique Lessard explains MTs are the “cellular roadways that kinesin/KIF […]

  4. 6

    […] body). Remember, healthy KIF1A (i.e. not mutated like what we see in KAND) is known for being “extremely effective at cargo transport.” So, if a virus wants to get around, why not hijack the “Porsche of motor proteins”? While […]

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